Extended Data Fig. 1: Identification of organ-enriched plasma proteins.
From: Organ aging signatures in the plasma proteome track health and disease
a, Plasma proteins for which the gene encoding the protein was expressed at least four-fold higher in one organ compared to any other organ were called “organ-enriched” in line with the definition proposed by the Human Protein Atlas. To calculate organ-level gene expression, the maximum expression of sub-tissues in the Gene Tissue Expression Atlas (GTEx) bulk RNA-seq database was used. An example of this tissue expression aggregation into organ expression CPLX1. (See ST2). b, Organ-wide expression for CPLX1. CPLX1 is expressed over four-fold higher in the brain compared to any other organ and is therefore defined as organ-enriched. c, Organ-level fold-change distribution of SomaScan plasma protein encoding genes. (See ST3). d, Organ-level expression of 843 organ-enriched plasma protein encoding genes. These 843 genes correspond to 893 plasma protein epitopes measured on the SomaScan assay. Some plasma proteins on the assay are quantified multiple times by different aptamers, which target different epitopes of the same protein. e, Top significantly enrichment biological pathways of brain-enriched plasma proteins.
