Extended Data Fig. 2: Structural comparison of TAAR1 with other aminergic receptors.
From: Ligand recognition and G-protein coupling of trace amine receptor TAAR1
a, Superposed structures of diverse agonist-bound TAAR1 with T1AM-hTAAR1. The root mean square deviation (RMSD) levels were calculated using T1AM-hTAAR1 structure as the reference. b, Structural superposition of T1AM-hTAAR1 structure with DRD1 (PDB:7CKZ), 5-HT4R (PDB:7XTA), β1AR (PDB:7BTS) and β2AR (PDB:3SN6), respectively. c, Structural comparison of T1AM-hTAAR1 with SEP-363856-hTAAR1 and RO-6889450-hTAAR1 (left panel) or T1AM-mTARR1 with SEP-363856-mTARR1 (right panel) revealed a similar ECL2 in TAAR1 receptor. d, Structural superposition of T1AM-hTAAR1 structure with SEP-363856-bound 5-HT1AR, dopamine-bound DRD1 (PDB:7CKZ) and adrenaline-bound β2AR (PDB: 3SN6).
