Fig. 5: Transcription factor modules across the whole mouse brain.
From: A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
a, Distribution of the number of differentially expressed transcription factors (TFs) between neuronal and non-neuronal classes, between classes, between subclasses, and within subclasses. b, Cross-validation accuracy for each cluster (left) or subclass (right) using classifiers built based on all 8,460 marker genes (all), 534 transcription factor marker genes (TF), 541 functional marker genes, 857 marker genes encoding adhesion molecules (adhesion), 534 randomly selected adhesion marker genes (random adhesion), or 534 randomly selected marker genes (random). c, Density plot showing distribution of correlation of marker gene expression between clusters using all markers, adhesion marker genes, functional genes and transcription factors. Correlation values are derived from full correlation matrices shown in Extended Data Fig. 3. d, Expression of key transcription factors for each subclass in the taxonomy tree, organized in transcription factor co-expression modules shown as colour bars on both sides of the heat map. Module IDs are shown on the left, exemplary transcription factor genes are shown on the right. For a full list of transcription factor genes in each module (in the same order as in this heat map), see Supplementary Table 8. Avg, mean.
