Fig. 4: Cytokine production map by cell type.
From: Dictionary of immune responses to cytokines at single-cell resolution
a, Heatmap of row-normalized gene expression of the 86 cytokines studied. Protein names encoded by the genes are in parentheses. b, Scatter plot showing the abundance of each cell type (log10 scaled) in lymph nodes in PBS-treated controls compared with the number of cytokine genes expressed (calculated from an equal number of cells per cell type; threshold of detection = 0.1). Smoothed conditional means and 95% confidence intervals from a fitted linear model are shown. Pearson correlation coefficient and its associated P value obtained from two-sided t-test are shown. a included all cells in the study, whereas b sampled an equal number of cells per cell type to ensure comparability across cell types. c, Cytokine-mediated cell–cell interactome shown for FRC and cDC1 cells (complete interactome presented in Extended Data Fig. 11). Asterisks indicate multimeric cytokines.
