Extended Data Fig. 9: Cytotoxic function of base edited T cells in arrayed validation. | Nature

Extended Data Fig. 9: Cytotoxic function of base edited T cells in arrayed validation.

From: Base-editing mutagenesis maps alleles to tune human T cell functions

Extended Data Fig. 9: Cytotoxic function of base edited T cells in arrayed validation.The alt text for this image may have been generated using AI.

Cytotoxicity (measured by A375 target cell killing) of antigen-specific T cells base edited with control, positive (increased T cell activation, red), or negative (decreased T cell activation, blue) guides targeting selected genes measured with Incucyte live-cell imaging over time. n = 6 human donors, shown as mean (line) ± SE (shaded area).

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