Extended Data Fig. 3: Base edits with strong functional effects are enriched in structured regions of proteins.
From: Base-editing mutagenesis maps alleles to tune human T cell functions
Scatter plot showing the correlation between AlphaFold predicted local Distance Difference Test (pLDDT) scores and screen LFC (log2-fold changes) for residues in proteins whose genes had |LFC | > 1.0 in the TNFα screen. Lower (<50) AlphaFold pLDDTs scores are predictive of structurally disordered regions of proteins. Predictions were obtained from pre-computed AlphaFold structures for canonical UniProt accessions for each screen gene.
