Extended Data Fig. 2: Taxonomy and functional characteristics of WLZ-associated MAGs.
From: Bioactive glycans in a microbiome-directed food for children with malnutrition
(a) Left subpanel, density plot showing WLZ-associated MAGs tabulated based on their genus-level classification. β1 refers to the coefficient in the linear mixed effects model presented at the bottom of the figure. Genera containing >3 significantly WLZ-associated MAGs are shown. Right subpanel, number of statistically significant WLZ-associated MAGs assigned to each genus depicted in the left subpanel. (b) Enrichment of metabolic pathways in WLZ- and treatment-associated MAGs. MAGs were ranked by their WLZ association (negative to positive) or treatment association (RUSF-associated to MDCF-2-associated) and GSEA was employed to determine overrepresentation of pathways in MAGs at the extremes of each ranked list. The results (Normalized Enrichment Score, NES) only include pathways that display a statistically significant enrichment (q<0.05, GSEA) in both the WLZ-associated MAG and treatment-associated MAG analyses. For carbohydrate utilization pathways, disaccharides and oligosaccharides are indicated with an asterisk.
