Extended Data Fig. 6: Structural comparison of apo and promoter-bound RSV polymerase (L:P).
From: Structures of the promoter-bound respiratory syncytial virus polymerase
The L and P proteins are almost identical in Le10-bound and TrC10-bound RSV polymerase structures. Thus, only Le10-bound RSV polymerase is used to align with the apo RSV polymerase. (a) Overall comparison of apo (gray) and Le10-bound RSV polymerases (L:P) (colored the same as Fig. 1). Compared with apo RSV L, the Cap domain of Le10-bound RSV L shifts inward by approximately 1.8 Å (red double-arrow), yielding a more compact catalytic pocket. (b) Structural comparison of the RdRp domains of the L protein between apo and Le10-bound RSV polymerases. The supporting helix and the supporting loop are colored orange. (c) Structural comparison of the Cap domains of the L protein between apo and Le10-bound RSV polymerases. The priming loop is colored orange. (d) Structural comparison of the RSV P between apo and Le10-bound RSV polymerases (L:P). The ‘GDN’ motif is shown in magenta spheres, and the ‘HR’ motif is shown in light brown spheres.
