Extended Data Fig. 2: Chemical structures of all compounds used in this study.
From: Adding α,α-disubstituted and β-linked monomers to the genetic code of an organism
(S)-3-amino-6-(((benzyloxy)carbonyl)amino)hexanoic acid ((S)-β3CbzK) (S1), (S)-6-acetamido-3-aminohexanoic acid ((S)-β3AcK) (S2), 6-(((benzyloxy)carbonyl)amino)hexanoic acid (CbzAhx) (S3), 3-amino-2-((1-ethyl-1H-imidazol-5-yl)methyl)propanoic acid (β2NeH (S4)), 3-amino-4-(4-bromophenyl)butanoic acid (β3pBrhF) (S5), 2-benzyl-3-hydroxypropanoic acid (β2OH-F) (S6), 3-amino-3-phenylpropanoic acid (β3F) (S7), (S)-6-((tert-butoxycarbonyl)amino)-2-hydroxyhexanoic acid (OH-BocK) (S8). N6-(tert-butoxycarbonyl)-L-lysine (BocK) (1), N6-((benzyloxy)carbonyl)-L-lysine (CbzK) (2), N6-((prop-2-yn-1-yloxy)carbonyl)-L-lysine (AlkyneK) (3), N6-benzoyl-L-lysine (BenzK) (4), 3-([2,2’-bipyridin]-5-yl)-2-aminopropanoic acid (BiPyA) (5), Nτ-methyl-L-histidine (NτmH) (6), (S)-2-amino-3-(thiophen-3-yl)propanoic acid (3-ThiA) (7), (S)-2-amino-3-(pyridin-3-yl)propanoic acid (PyA) (8), (S)-2-amino-3-(4-iodophenyl)propanoic acid (pIF) (9), (S)-2-amino-3-(4-bromothiophen-2-yl)propanoic acid (BrThiA) (10), (2 S)-2-amino-3-(((2-((1-(6-nitrobenzo[d][1,3]dioxol-5yl)ethyl)thio)ethoxy)carbonyl)amino)propanoic acid (pcDAP) (11), N6-(tert-butoxycarbonyl)-aminohexanoic acid (BocAhx) (12), (S)-3-amino-3-(3-bromophenyl)propanoic acid ((S)β3mBrF) (13), (S)-3-amino-3-(benzo[d][1,3]dioxol-5-yl)propanoic acid ((S)β3MDF) (14), (S)-3-amino-3-(4-bromophenyl)propanoic acid ((S)β3pBrF) (15), (S)-3-amino-3-(3,4-difluorophenyl)propanoic acid ((S)β3pmFF) (16), (S)-3-amino-3-(2-bromophenyl)propanoic acid ((S)β3oBrF) (17), (S)-3-amino-3-(3-(trifluoromethyl)phenyl)propanoic acid (18) ((S)β3mCF3F), (S)-2-amino-3-(4-iodophenyl)-2-methylpropanoic acid (19) ((S)α-Me-pIF), (S)-3-(3-chlorophenyl)-3-hydroxypropanoic acid (20) (OH-(S)β3mClF).
