Extended Data Fig. 6: Model evaluation on positive and negative control sequences.
From: Targeted design of synthetic enhancers for selected tissues in the Drosophila embryo
Predicted enhancer activity scores by the sequence-to-activity transfer learning models for validated inactive sequences, all known active enhancers, and for known enhancers in the marker gene loci of the respective tissues. Gene loci (+/−50kb): elav (CNS), grh (epidermis), GATAe (gut), Mef2 (muscle) and tll (brain). P-values from two-sided Wilcoxon rank-sum test are shown for each comparison between inactive and active sequences per tissue. Number of sequences in each boxplot is shown in the respective x-axis. The boxplots mark the median, upper and lower quartiles and 1.5× interquartile range (whiskers); outliers are shown individually.
