Extended Data Fig. 4: Mucosal and peripheral IgG spike-specific binding antibody responses by ECLA. | Nature

Extended Data Fig. 4: Mucosal and peripheral IgG spike-specific binding antibody responses by ECLA.

From: Mucosal boosting enhances vaccine protection against SARS-CoV-2 in macaques

Extended Data Fig. 4: Mucosal and peripheral IgG spike-specific binding antibody responses by ECLA.

IgG spike-specific binding antibody responses were assessed before and after boosting by meso-scale discovery (MSD) electrochemoluminscent assay in (a) bronchoalveolar lavage (BAL), (b) nasal swabs (NS), and (c) serum. Responses were measured against SARS-CoV-2 WA1/2020 (blue), BA.1 (green), BA.5 (purple), and BQ.1.1 (black) spike proteins. Missing symbols indicate absence of data. Dotted lines represent limits of quantitation. Medians (red bars) are shown. Relative light units are shown. n = 40 biologically independent animals.

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