Extended Data Fig. 1: Low affinity RFjoint-Inpainted binders for NPY and GCG using extended parametric designs.
From: De novo design of high-affinity binders of bioactive helical peptides
(a) Left: Design model (colour spectrum + yellow) of the tightest GCG binder. Right: FP titration (n = 4) for the tightest GCG binder indicates ~ 231 nM binding affinity (b) Left: Design model (colour spectrum + dark green) of the tightest NPY binder. Right: FP titration (n = 4) for the tightest NPY binder indicates 3.5 µM binding affinity.
