Fig. 3: All of Us LDL-C GWAS. | Nature

Fig. 3: All of Us LDL-C GWAS.

From: Genomic data in the All of Us Research Program

Fig. 3: All of Us LDL-C GWAS.

Manhattan plot demonstrating robust replication of 20 well-established LDL-C genetic loci among 91,749 individuals with 1 or more LDL-C measurements. The red horizontal line denotes the genome wide significance threshold of P = 5 × 10–8. Inset, effect estimate (β) comparison between NHLBI TOPMed LDL-C GWAS (x axis) and All of Us LDL-C GWAS (y axis) for the subset of 194 independent variants clumped (window 250 kb, r2 0.5) that reached genome-wide significance in NHLBI TOPMed.

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