Table 1 cis-pQTLs and trans-pQTLs for induced cytokines in each stimulation
From: Smoking changes adaptive immunity with persistent effects
Stimulus | Cytokine | rsID | Adjusted P value | cis or trans | Locus |
|---|---|---|---|---|---|
E. coli | IFNγ | rs4833095 | 5.45 × 10−26 | trans | TLR1/6/10 locus |
IL-2 | rs9306967 | 2.83 × 10−33 | trans | TLR1/6/10 locus | |
IL-6 | rs5743614 | 1.07 × 10−34 | trans | TLR1/6/10 locus | |
IL-8 | rs4833095 | 5.64 × 10−52 | trans | TLR1/6/10 locus | |
IL-17a | rs9306967 | 9.24 × 10−21 | trans | TLR1/6/10 locus | |
IL-23a | rs6815814 | 4.50 × 10−30 | trans | TLR1/6/10 locus | |
LPS | CXCL5 | rs352045 | 5.13 × 10−15 | cis | CXCL5 promoter |
IL-1β | rs3764613 | 1.96 × 10−10 | trans | PPP5C enhancer | |
IL-6 | rs62449491 | 7.58 × 10−10 | cis | IL6 enhancer | |
IL-10 | rs1518110 | 3.39 × 10−08 | cis | IL10 intronic enhancer | |
IL-12a/b | rs143060887 | 1.37 × 10−10 | cis/trans | IL12A putative regulatory regions | |
SEB | IL-6 | rs11936050 | 1.30 × 10−27 | trans | TLR1/6/10 locus |
Anti-CD3 + CD28 (responders) | CXCL5 | rs352045 | 1.33 × 10−36 | cis | CXCL5 promoter |
IL-2 | rs1801274 | 2.09 × 10−22 | trans | Close to FCGR2A | |
BCG | CXCL5 | rs10013453 | 6.64 × 10−12 | trans | TLR1/6/10 locus |
IL-2 | rs4833095 | 1.01 × 10−66 | trans | TLR1/6/10 locus | |
IL-6 | rs72636686 | 8.92 × 10−12 | trans | KAZN intron | |
IL-8 | rs4833095 | 7.21 × 10−109 | trans | TLR1/6/10 locus | |
C. albicans | CXCL5 | rs10779330 | 9.21 × 10−16 | trans | CR1 locus |
IL-1β | rs10863358 | 9.56 × 10−15 | trans | CR1 locus | |
IL-23a | rs10779330 | 2.70 × 10−10 | trans | CR1 locus | |
TNF | rs11117956 | 9.46 × 10−15 | trans | CR1 locus | |
Influenza | CXCL5 | rs352045 | 3.24 × 10−59 | cis | CXCL5 promoter |
CXCL5 | rs10822168 | 1.88 × 10−14 | trans | JMJD1C intron | |
IL-6 | rs35345753 | 1.61 × 10−07 | cis | IL6 enhancer | |
Poly I:C | CXCL5 | rs352045 | 7.15 × 10−59 | cis | CXCL5 promoter |
CXCL5 | rs10822168 | 5.01 × 10−15 | trans | JMJD1C intron | |
IFNγ | rs3775291 | 1.36 × 10−13 | trans | TLR3 exon | |
IL-1β | rs3775291 | 1.76 × 10−24 | trans | TLR3 exon | |
IL-6 | rs62449491 | 3.37 × 10−07 | cis | IL6 enhancer | |
IL-6 | rs3775291 | 1.46 × 10−17 | trans | TLR3 exon | |
IL-12a/b | rs3775291 | 1.92 × 10−22 | trans | TLR3 exon | |
TNF | rs113845942 | 1.57 × 10−07 | cis | HLA-DRB intergenic region | |
TNF | rs3775291 | 4.78 × 10−19 | trans | TLR3 exon | |
TNF | CSF2 | rs112997843 | 1.11 × 10−09 | trans | Intergenic region |
CXCL5 | rs352045 | 1.95 × 10−22 | cis | CXCL5 promoter | |
IFNγ | rs352045 | 2.38 × 10−14 | trans | CXCL5 promoter | |
IL-10 | rs6689179 | 1.58 × 10−07 | cis | IL10 enhancer | |
IL-1β | CXCL5 | rs352045 | 5.09 × 10−32 | cis | CXCL5 promoter |
CXCL5 | rs2393969 | 6.35 × 10−10 | trans | JMJD1C intron | |
IFNγ | rs2564594 | 1.07 × 10−11 | trans | CXCL5 promoter | |
IFNγ | CXCL5 | rs352045 | 8.06 × 10−58 | cis | CXCL5 promoter |
CXCL5 | rs10822168 | 1.49 × 10−14 | trans | JMJD1C intron |
