Extended Data Fig. 8: Trp-CLiC targets functional cation-π interactions and reveals a privileged WxxxK cation-π motif.
From: Oxidative cyclization reagents reveal tryptophan cation–π interactions
a) The diversity of cation sources, such as DNA, RNA, protein, lipid, other ligands or metal ions, to form cation-π interactions with tryptophan, highlights the uniqueness of Trp cation-π interactions. b) Trp-CLiC ABPP showed the enrichment of targeting WxxxK cation-π motif. Seven examples are listed here.
