Extended Data Fig. 1: The Trp metabolites I3A, IPyA, and IEt protect against Citrobacter rodentium infection in mice.
From: Dopamine receptor D2 confers colonization resistance via microbial metabolites
C57Bl/6 mice were pre-treated with antibiotics (ABX) for 7 d, followed by Trp metabolites, I3A (1000 mg/kg), IPyA (2900 mg/kg), or IEt (600 mg/kg) by oral gavage daily for 2 d. The mice were then administered C. rodentium (CR, oral gavage, 108 CFU) with continued ABX (except neomycin) and metabolite treatment for 10 d. Colon sections were stained with H&E. Shown are representative images. Scale bar: 50 μm. Data are representative of at least 3 independent experiments, n = 10 mice per group.
