Extended Data Fig. 6: Selective activation of hippocampal GABAergic cells during DS2 vs. SPW-R.
From: Neural and behavioural state switching during hippocampal dentate spikes
a, Calcium imaging of axoaxonic cells (AAC) was performed on awake behaving mice while contralateral electrodes captured hippocampal LFP events for panels. Image is averaged across movie frames from a representative recording (n = 3 mice). Scale bar = 50 μm. b, Representative calcium dynamics of 3 AACs during facial and locomotor movements. Hippocampal events are denoted by vertical bars. c, Histogram of correlation coefficients (r) for AAC calcium vs. facial movements (n = 25 cells, 3 mice). d, Average (±sem) AAC calcium activity aligned to hippocampal LFP events. Repeated measures one-way ANOVA, F2,48 = 38.32, P < 0.0001. Two-sided Tukey post-test. e, Average (±sem) AAC calcium changes aligned to air puff or tone onset. Two-sided within-subject t-test, t24 = 2.50. Pie charts show the percent of trials that evoke DS2 (n = 3 mice). Data were collected in the authors’ lab. f, Theta Off, Ripple On (TORO) cells identified in Szabo et al., 202221 plotted in orange vs. all other cells recorded in the Allen Institute dataset. g, Event-triggered average firing rates of TORO cells for each event type. Repeated measures one-way ANOVA, F2,34 = 80.49, P < 0.0001.
