Extended Data Fig. 6: Further therapeutic data for ¹⁷⁷Lu- or ²²⁵Ac-labelled CTR-FAPIs.

a–c, NU/NU mice were implanted subcutaneously with HT-1080-FAP cells, followed by intravenous injection of saline, [¹⁷⁷Lu]Lu-FAPI-04, [¹⁷⁷Lu]Lu-FAPI-mFS. n = 7 mice for each group of [¹⁷⁷Lu]Lu-FAPI-mFS, n = 8 mice for saline and [¹⁷⁷Lu]Lu-FAPI-04. a, Maximum tumour response waterfall plot till Day 30. b, Tumour volume curve of an individual mouse. c, Photographs of representative tumours at day 14 in a repeated trial. d–g, NU/NU mice were implanted subcutaneously with HT-1080-FAP cells, followed by intravenous injection of saline, [²²⁵Ac]Ac-FAPI-04 or [²²⁵Ac]Ac-FAPI-mFS. d, Treatment scheme. n = 6 mice for each group of [²²⁵Ac]Ac-FAPI-mFS 22.2 kBq, n = 7 mice for saline, [²²⁵Ac]Ac-FAPI-04 and [²²⁵Ac]Ac-FAPI-mFS 33.3 kBq. e, Tumour volume curves of the group. f, Maximum tumour response waterfall plot. g, Tumour volume curves of an individual mouse. Two-tailed unpaired Student’s t-test was applied (e on day ~15). h, Selected results from complete blood count (CBC) and blood biochemistry tests. ALT = Alanine aminotransferase; AST = Aspartate aminotransferase; ALB = Albumin; UREA = Urea in serum; CREA = Serum creatinine. n = 3, data shown are mean ± s.d (e,h). One-way ANOVA followed by Tukey’s multiple comparison test was applied.

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