Extended Data Fig. 2: Chemical structures, target affinity and stability profile of CTR-FAPIs and related molecules.
From: Covalent targeted radioligands potentiate radionuclide therapy
a, Chemical structures of the CTR-FAPI vectors and fluorescent probes discussed in this work. b, IC50 values obtained by in-cell competitive binding assay with [68Ga]Ga-FAPI-04. Every test was performed at least twice individually. c, Representative IC50 curves of FAPI-04, FAPI-pFS and FAPI-mFS competing with [68Ga]Ga-FAPI-04 to bind HT-1080-FAP cells (n = 4). d, Representative IC50 curves of FAPI-04, FAPI-pFS and FAPI-mFS tested in enzyme activity inhibition assays to evaluate the FAP binding selectivity (n = 4). e, Evaluation of the stability of FAPI-SF, FAPI-pFS and FAPI-mFS vectors under common 68Ga-labelling condition or physiological condition by UPLC. Data are mean ± s.d. (c,d).
