Extended Data Fig. 2: Structural evolutionary trajectory analysis of II-C Cas9s.
From: Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity
a, SGT analysis plane maps to emerging structural features. The size of the point corresponds to Cas9 size and the colour corresponds to different structural features. b, Schematic illustrating three evolutionary trajectories and representative II-C Cas9 models at checkpoint of each evolutionary trajectory. The emerging domains are coloured and labelled according to a. c, SGT analysis plane maps to NAG association. The size of points corresponds to Cas9 size and the colour corresponds to different NAG association.
