Extended Data Fig. 1: Construction of a molecular single-cell atlas of the human brain vasculature across development, adulthood and disease and of the fetal peripheral vasculature - studied entities and inter-tissue heterogeneity.
From: Single-cell atlas of the human brain vasculature across development, adulthood and disease
Figure shows studied entities and inter-tissue heterogeneity of sorted vascular endothelial cells. a,b, Scheme of the different tissue types present in the study with respective sample/patient numbers of fetal (a) and adult (b) origins. c, Piechart showing relative abundance and percentage of ECs from each tissue collected. d, Composite UMAP plots of sorted and in silico-quality checked (ECs, coloured by tissue of origin. e, Violin plots of the expression of the top marker genes of each tissue type, percentage of cells expressing the marker gene is indicated on the right. f, Endothelial cells transcriptome correlation heatmap and hierarchical clustering of all tissues analysed. g, Dotplot heatmap of the fetal brain vs fetal periphery endothelial signature. h, Expression heatmap of top ranking marker genes in the indicated tissues. Colour scale: red, high expression; white, intermediate expression; blue, low expression.
