Extended Data Fig. 8: Strategy for the generation of a floxed ICER knockout mouse to achieve a T cell-specific ICER knockout. | Nature

Extended Data Fig. 8: Strategy for the generation of a floxed ICER knockout mouse to achieve a T cell-specific ICER knockout.

From: A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection

Extended Data Fig. 8: Strategy for the generation of a floxed ICER knockout mouse to achieve a T cell-specific ICER knockout.

a, Illustration of the genomic region encompassing the ICER-specific exon as well as the alternative promoters driving expression of ICER and smICER, respectively and of the flanked by loxP sites used for homologous recombination in mouse ES cells. b, illustration of the strategy for generating the Icerfl allele.

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