Extended Data Fig. 2: Transcriptional regulation of antigen-specific CD8 T cells after resolved and during persistent hepatotropic viral infection and LCMV infection. | Nature

Extended Data Fig. 2: Transcriptional regulation of antigen-specific CD8 T cells after resolved and during persistent hepatotropic viral infection and LCMV infection.

From: A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection

Extended Data Fig. 2: Transcriptional regulation of antigen-specific CD8 T cells after resolved and during persistent hepatotropic viral infection and LCMV infection.

a, Expression of tissue signature genes extracted from GSEA by CD45.1+CXCR6+CD8 T cells (n = 3). b, GSEA of liver CD45.1+CXCR6+CD8 T cells compared to spleen CD45.1+CX3CR1+CD8 T cells (n = 3). c, GSEA for CREM-dependent genes in liver LCMV gp33-specific CXCR6+CD8 T cells after LCMV Armstrong compared to LCMV clone 13 infection (permutation test with Benjamini-Hochberg FDR, n = 3). d,e, UMAP clusters of publicly available scRNA-seq of liver CD8 T cells during persistent LCMV infection90 and GSEA for CREM transcription factor target genes, no enrichment was found for clusters 1, 3, 6 (permutation test with Benjamini-Hochberg FDR). false discovery rate (FDR).

Source Data

Back to article page