Extended Data Fig. 4: Transcriptional profiles of circulating HBV-specific CD8 T cells in patients with chronic Hepatitis B.
From: A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection
a, GSEA for cAMP signalling/CREM dependent genes with non-HBV-specific bulk CD8 T cells in chronic hepatitis B patients compared to patients with resolved infection (n = 5). b,c, Transcription factor activity analysis in circulating HBcore-specific CD8 T cells in two cohorts (n = 3 and n = 4) of chronic hepatitis B patients, top 20 transcription factors with enhanced activity are shown for each patient. d,e, UMAP and Ucell cAMP/CREM signature score analysis for circulating HBcore-specific CD8 T cells from four patients with chronic hepatitis B (Wilcoxon test). f, GSEA for cAMP signalling/CREM dependent genes with CD8 T cells in patients with persistent compared to controlled HIV infection31 (n = 4).
