Extended Data Fig. 13: CryoEM atomic model versus subtomogram map Fourier shell correlation.
From: CryoET of β-amyloid and tau within postmortem Alzheimer’s disease brain
a, For reference, Fourier shell correlation of previously reported single-particle cryoEM structure of ex vivo sarkosyl-extracted PHF (PDB: 5o3l) and map (EMDB-3741)24. b, Fourier shell correlation of PHF (PDB 5o3l) and cryoEM map of ex vivo sarkosyl-extracted PHF from donor (Extended Data Fig. 1i). c-l, Fourier shell correlation of PHF (PDB 5o3l) or SF (PDB 5o3t) atomic model24 versus subtomogram average maps corresponding to Fig. 3h PHF, Fig. 4h PHF, Fig. 4h SF, Fig. 4j SF and Extended Data Fig. 9a–f, respectively. Resolution estimates based on Fourier shell correlation of half-maps annotated in parenthesis. See also Supplementary Data Table 5.
