Fig. 3: Characterization of excitatory neuron M-types.
From: Inhibitory specificity from a connectomic census of mouse visual cortex
a, Morphology (black) and synapse (cyan dots) properties were used to extract features for each excitatory neuron, such as this layer 2/3 pyramidal cell. b, Heatmap of Z-scored feature values for all excitatory neurons, ordered by anatomical cluster (Fig. 5) and soma depth. Anatomical properties were tip length, tortuosity, dendritic and somatic synapse counts, total path length, radial extent, median synapse distance from soma, somatic and dendritic synapse sizes, dynamic range of synapse size, shallowest and deepest ranges of synapse depth, range of synapse depths, linear synapse density and dendritic radius. All synapse measures use synaptic inputs only. See Methods for detailed feature descriptions. c, Uniform manifold approximation and projection (UMAP) of neuron features coloured by anatomical cluster. Inset shows number of cells per cluster. d, Example morphologies for each cluster. Scale bar, 500 µm. e, Soma depth of cells in each anatomical cluster. f, Median linear density of input synapses across dendrites by M-type. g, Median synapse size (Methods). In f and g, coloured dots indicate single cells; black dots and error bars indicate a bootstrapped (n = 1,000) estimate of the median and 95% confidence interval. a.u., arbitrary units.
