Fig. 5: Inhibitory motif groups organize inhibitory connectivity.
From: Inhibitory specificity from a connectomic census of mouse visual cortex
a, Distribution of synaptic output for all interneurons, clustered into motif groups with common target distributions. Each row is an excitatory target M-type, each column is an interneuron, and colour indicates fraction of observed synapses from the interneuron onto the target M-type. Only synapses onto excitatory neurons are used to compute the fraction. Neurons are ordered by motif group and soma depth. Bar plots along top indicate number of synapses onto column cells, with colour showing subclass (as in d). Bar plots along right indicate number of cells in target M-type. b,c, Morphology of all cells in group 4 (b) and group 13 (c), with colours as in a. Scale bar, 500 µm. d, Soma depth and subclass for cells in each motif group. Scale bar, 200 µm. e, Net synaptic output distribution across M-types for each motif group. f, Synaptic input for each M-type from each motif group as a fraction of all within-column inhibition. g, Schematic of motif group connectivity in upper layers. h, Schematic of motif group connectivity in Layer 5.
