Extended Data Fig. 5: Metabolic phenotype of male PTER-KO mice on a chronic treadmill exercise training protocol.
From: PTER is a N-acetyltaurine hydrolase that regulates feeding and obesity
Related to Fig. 4. a-c, Running distance (a), running time (b) and maximum speed (c) of 10- to 11-week-old male PTER-KO mice (N = 10, blue line and box) or WT mice (N = 9, orange line and box) following a single bout of treadmill exercise running until exhaustion. d-l, Change in body weight (d), body weight (e), cumulative food intake (f), glucose tolerance test (g), insulin tolerance test (h), tissues weights (i), representative adipose tissues (j), plasma taurine levels (k), and plasma N-acetyltaurine levels (l) of 10- to 11-week-old male PTER-KO mice (N = 10, blue line and box) or WT mice (N = 8, orange line and box) after a 6-week treadmill exercise training protocol (see Methods). For i, WT versus PTER-KO BAT, P = 1.41e-04; iWAT, P = 6.98e-04, eWAT, P = 103e-03. For l, WT versus PTER-KO pre-exercise, P = 2.94e-08; post-exercise, P = 8.98e-10. Data are shown as mean ± SEM. In a-c and i-l, P-values were calculated from two-tailed unpaired t-tests and were not corrected for multiple comparisons. In d-h, P-values were calculated from two-way ANOVA with post hoc Sidak’s multiple comparisons test.
