Extended Data Fig. 9: PARIS activation results in DNA compactization akin to inhibition of translation with chloramphenicol.
From: A virally encoded tRNA neutralizes the PARIS antiviral defence system
a, Hi-C contact maps (bin: 4kb). From left to right: WT (pFR66 + pFD245 control vectors), PARIS (pFR85) + PPhlF-ocr (pFD250), and chloramphenicol treated cells. Top and bottom rows correspond to 15 and 30 min after induction with DAPG or treatment with chloramphenicol. b, Ratio between contact maps of WT at t = 30 min and contact maps 30 min after either PARIS activation (left) or chloramphenicol treatment (right).
