Extended Data Fig. 3: Genomic alterations in Brca1;Trp53 confetti clones and end stage tumours.
From: Mechanisms that clear mutations drive field cancerization in mammary tissue
a, DNA copy number profiles in untransformed (top) and transformed (middle) Brca1;Trp53 confetti clones 225 days after Cre-recombination, and in Brca1;Trp53 end-stage tumours (bottom). b, Example of genomic events that occur early in Brca1;Trp53 tumorigenesis. DNA copy number profiles of chromosome 12 showing genomic losses that are found in early transformed and untransformed Brca1;Trp53 clones, as well as in end-stage tumours. c, Example of genomic events occurring late in Brca1;Trp53 tumorigenesis. DNA copy number plots of chromosome 6 showing copy number changes that are unique to end-stage Brca1;Trp53 tumours, but not found in early clones. All plots show averages of 3 mice (225d timepoint: 13 transformed clones and 13 untransformed clones) and 10 mice (end-stage tumours).
