Fig. 2: Despite similar gene expression, NSCs possess a unique methylome that distinguishes them from other astrocytes.
From: DNA methylation controls stemness of astrocytes in health and ischaemia
a, Correlation matrices and hierarchical clustering of gene expression and DNA methylation data, averaged for each cell state. Left, correlation of log-normalized expression values for genes expressed in at least 10% of cells. Right, correlation of methylation values for the 40,000 VMRs with the highest sequencing coverage. b, Motif enrichment of VMRs with low methylation in astrocytes (vSVZ and striatum) or cells of the neurogenic lineage. The scatter plots of transcription factors (TFs) show the unadjusted one-sided enrichment P values reported by HOMER61 for the transcription factor motif on the y axis, and the mean gene expression for the transcription factor in the respective cell population on the x axis. Human transcription factors are set in all upper case and mouse transcription factors are set with initial upper case only.
