Fig. 5: Preparatory activity is led by TF-responsive subpopulations.
From: Brain-wide dynamics linking sensation to action during decision-making
a, Left, mean responses to a fast TF pulse of five example TF-responsive units in MOs (top) and responses to a fast TF pulse for all TF-responsive units in MOs (z-scored firing rate) (bottom). Right, activity of the same neurons aligned to early lick onset. b, Same as a, but for TF-responsive units in SCs. Horizontal black lines indicate windows of activity used to calculate the alignment of population vectors in c. c, Alignment (Pearson correlation; P value based on t-statistic) between responses (baseline subtracted) of TF-responsive MOs or SCs units to a fast TF pulse and their preparatory activity before the early lick. d, Mean alignment of population vectors (correlation in c) for each group of brain regions (bootstrap test). See Supplementary Table 1 for n of each brain region group. e, Fraction of significantly active units (P < 0.01, z-test) as a function of time, shown separately for TF-responsive and TF non-responsive units for six example brain regions. Values of n for each brain region are presented in Supplementary Table 1. f, Fraction of active TF-responsive units (thresholded by lower 95% confidence interval greater than zero, bootstrap test) as a function of time from the hit-lick onset, shown for each brain region. Brain regions are sorted according to the time of the earliest, significantly active fraction (black line; Methods). g, Same as f, but for the TF non-responsive subpopulation. h, Relationship between the onset of preparatory activity in TF-responsive units and their median response duration to a fast TF pulse across brain regions. Pearson correlation and corresponding P value from t-statistic are shown on top. In all panels, shaded regions and error bars indicate 95% confidence interval. See Supplementary Table 2 for definitions of brain region abbreviations.
