Fig. 5: Mechanical friction redirects tissue motion/axis formation, inducing ectopic embryo formation.
From: Self-organized tissue mechanics underlie embryonic regulation
a–h, Model predictions (a–d) and the experimental response (e–l) to localized friction. a,e, Sketch of the experiment (a) and memGFP embryo with a hair on its ventral side (e). b,f, Profiles of contractility (magenta), tension (green) and velocity (black) along the margin at t0 + 4 h; 0 mm is posterior. c,g, Kymograph of margin strain rates; 0° is posterior. d,h, Deformation maps at 8 h (d) and 14 h (h) after hair deposition. n = 33 out of 34 biologically independent embryos. i–l, GDF1 (i; the arrowheads point to ectopic expression), BRA (j) and SOX3 (k) expression and the corresponding deformation map (l), 4.5 h after hair deposition (grey box). n = 15 biologically independent embryos. Colours in c, d, g, h and l quantify contraction (red) and expansion (blue) as in Fig. 1. Scale bars, 1 mm (e and h–l).
