Extended Data Fig. 9: Cardiac fibroblasts in irMyocarditis and graphical abstract summarizing key findings.
From: Immune responses in checkpoint myocarditis across heart, blood and tumour
a, Feature plots using colour to indicate marker gene expression (logCPM) levels of the indicated genes projected onto the heart fibroblast UMAP embedding. Cell numbers and percentages represent gene expression across all heart fibroblast and myofibroblast cells. b, Abundance analysis comparing intramyocardial frequencies of cell populations from pre-steroid irMyocarditis heart samples (n = 12, red) versus controls (n = 8, blue). Left: dots represent logistic regression odds-ratios. Error bars represent 95% confidence intervals. Unadjusted two-sided likelihood-ratio test P values for each subset are shown. Right: box plots display the median (line) and IQR, with whiskers no more than 1.5x IQR. Each dot represents one patient. c, Volcano plot of the genes within the fibroblast lineage modeled by serum troponin T, with select genes highlighted. Coloured points represent FDR < 0.1 (two-sided Wald test). d, Summary of key findings. Clusters whose abundances correlated with serum troponin T levels were considered correlates of disease severity. Abbreviations: FB, fibroblast. Related to Fig. 5.
