Extended Data Fig. 5: Focal amplifications and interchromosomal ecDNA.

a, (top) Boxplots of focal amplification copy number for ecDNA (red) and chromosomal amplifications (yellow) grouped by cancer type. (bottom) Violin plot of the number of ecDNA observed per tumour grouped by cancer type. b, (left) schematic demonstrating the concept of interchromosomal ecDNA. (right-top) Strip plot showing the count of interchromosomal ecDNA breakpoints for interchromosomal ecDNA (red) and non-interchromosomal ecDNA (light grey) grouped by cancer type. (right-bottom) Stacked bar plot showing the proportion of ecDNA observed for each cancer type that is interchromosomal (red) or non-interchromosomal (grey). The graphics in the schematic were created with BioRender.com. c, Heatmaps depicting chromosome pairs involved in interchromosomal ecDNA for liposarcoma, osteosarcoma, HER2+ breast cancer and luminal breast cancer.