Extended Data Fig. 1: Bacterial hosts that Tad-encoding phage likely infect contain multiple CBASS CD-NTases that produce cyclic oligonucleotides.
From: Single phage proteins sequester signals from TIR and cGAS-like enzymes
Bacteria from the genus (a) Clostridium, (b) Bacteroides, (c) Sphingobacterium, and (d) Bacillus cereus group contain CBASS CD-NTases that produce cyclic oligonucleotides (c-oligos) with strong, weak, or no binding affinity to the Tad proteins tested in this study. The relative frequency of CD-NTases is quantified as the number of CD-NTase from a specific clade divided by the total number of CD-NTases identified using the NCBI blastp (see Methods for details). The legend indicates the c-oligos that are known or predicted to be produced by the indicated CBASS CD-NTases (Whiteley et al.22; Ye et al.34; Morehouse et al.40; Fatma et al.23). CD-NTases with currently unknown nucleotide products are indicated in the legend and the graphs.
