Extended Data Fig. 7: Transcriptional changes persist weight loss in epiAT.
From: Adipose tissue retains an epigenetic memory of obesity after weight loss
a, Number of upregulated (left) and downregulated (right) DEGs per cell type per comparison (H vs C, HC vs CC, HH vs CC, HHC vs CCC) scaled by column. b, Proportion of retained transcriptional changes in different cell types. (Wilcoxon Rank Sum test, adjusted p-value < 0.05 by the Bonferroni correction method; FC > ±0.5). c,d, Top (significant) persistently upregulated (memory) (c) and downregulated (d). pathway terms in HC adipocytes based on Wikipathways database. e,f, Significant Wikipathways term enrichment scores related to persistently upregulated genes in HHC (f) and HC (g) per cell type. g,h, Significant Wikipathways term enrichment scores related to persistently downregulated genes in HHC (f) and HC (g) per cell type. Significance for c-h was calculated using Fisher’s exact test, with adjusted P-value < 0.05 by the Benjamini-Hochberg method for correction. APCs, adipocyte progenitor cells; DCs, dendritic cells; EpiCs, epithelial cells; EndoCs, endothelial cells; FIPs, fibro-inflammatory progenitors; LECs, lymphatic endothelial cells; MastCs, mast cells; MesoCs, mesothelial cells; SMCs, (vascular) smooth muscle cells; NPVMs, non-perivascular macrophages; LAMs, lipid-associated macrophages; PVMs, perivascular macrophages; P-LAMs, proliferating LAMs.
