Fig. 4: Adipocyte enhancers retain an epigenetic memory.
From: Adipose tissue retains an epigenetic memory of obesity after weight loss
a, Correlation coefficient R (Pearson) of quantified peaks of H3K4me1 and H3K4me3 against a hypothetical healthy control (n = 2–3 each) with s.d. Each dot represents an individual biological replicate. b, PCA plots of quantified adipocyte-specific enhancers as marked by H3K4me1. Each dot represents an individual biological replicate. c, Dynamics of differentially H3K4me1-marked enhancers (y axis) from H to HC (left) and HH to HHC (right). d, H3K27ac status of genes linked to newly emerged enhancers marked by H3K4me1 (from c) in different conditions identified by the presence of an H3K27ac peak associated to the gene. n = 218 left and n = 127 right. e, Top (significant) pathway terms for genes linked to newly emerged acetylated enhancers for H and HC (left) and HH and HHC (right) on the basis of WikiPathways database (Fisher’s exact test, adjusted P < 0.05 by the Benjamini–Hochberg method for correction). f, Proportion of down- and upregulated memory DEGs from TRAP–seq that can be explained by one or more epigenetic modality in HC (n = 13; n = 72) and HHC (n = 7; n = 36).
