Extended Data Fig. 8: Additional interfaces.
From: Structure of apolipoprotein B100 bound to the low-density lipoprotein receptor
Ribbon diagrams of Nb4 binding apoB100 (a), LA2 binding the protein A domain in MBP (b) and LA3, LA4 and LA6, respectively, binding to apoB100 (c–e). Locations of FH variants in apoB100 are circled (red dashed ovals). Each is coloured as in Fig. 3 and by heteroatom. f, EGF-C is apparent at a very low density threshold. Superpositioned cryo-EM reconstructions of the 2:2:2 complex (white, 7.89 Å, 0.05 density threshold) and β-propeller (pink) and β-barrel (blue) (4.83 Å). LDL, density bridge, and select domains are labelled. Features of interest are labelled.
