Extended Data Fig. 2: Lifetime risks of breast and ovarian cancer associated with categories of pathogenic and benign variants. | Nature

Extended Data Fig. 2: Lifetime risks of breast and ovarian cancer associated with categories of pathogenic and benign variants.

From: Functional evaluation and clinical classification of BRCA2 variants

Extended Data Fig. 2: Lifetime risks of breast and ovarian cancer associated with categories of pathogenic and benign variants.

A,B, Lifetime risk estimates for breast cancer (A) and ovarian cancer (B) associated with categories (P_Strong, P_Strong/Moderate/Supporting, B_Strong, B_Strong/Moderate/Supporting) of BRCA2 DNA binding domain SNVs from the BRCA2 MAVE study. Standards included known pathogenic (all protein truncating alterations), known benign (benign variants established by the ClinGen BRCA1/2 VCEP), general population breast/ovarian (age related risks of these cancers from the general SEER registry).

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