Extended Data Fig. 6: Ultrasound-triggered drug release from different HOF nanocrystals.
From: H-bonded organic frameworks as ultrasound-programmable delivery platform
a, HOF-TATB. b, HOF-BTB. c, HOF-101. d, HOF-102. The fluorescence dye RB was first loaded into the HOF nanocrystals. After that, the ultrasound irradiated the RB-loaded nanocrystals with different power densities. At fixed time points, the solution was taken out and centrifuged. The released RB concentration was determined through UV-Vis from the supernatant. Mean ± s.e.m., n = 3 independent experiments for each sample. e–h, Ultrasound-triggered drug release from HOF-TATB. The fluorescence dye RB was first loaded into the HOF-TATB nanocrystals (TATB@RB). After that, the TATB@RB nanocrystals were irradiated by the ultrasound with different power densities, including 0.51 MPa (e), 0.89 MPa (f) and 1.08 MPa (g), and the quantification of drug release percentage without ultrasound and with ultrasound for 90 s (h). Mean ± s.e.m., n ≥ 3 independent samples. One-way ANOVA and Dunnett’s multiple comparison tests (P ≥ 0.05 (ns), *0.01 ≤ P < 0.05, **0.001 ≤ P < 0.01, ****P < 0.0001). Mean ± s.e.m., n = 3 independent experiments for each sample.
