Extended Data Fig. 5: Pairplots of replicate fitness values.

Fitness values for each mutant are calculated as described in the methods for each replicate individually. These replicates are 3 sets of technical replicates of 3 biological replicates. Replicates 1, 4 and 7 are technical replicates (same with 2/5/8 and 3/6/9). Replicates 7–9 were collected on a different day. Pearson correlations reported for each pair of replicates. The distribution of fitness values is reported along the diagonal and pairwise correlations are reported between replicated off the diagonal. Pearson R is reported in the bottom-left half.