Fig. 2: Cell-type taxonomy of the human hypothalamus.

Hierarchical consensus tree (circular dendrogram) of human cell types based on unbiased clustering of the integrated snRNA-seq data. Nodes correspond to clusters at each level in the tree. At the highest level (C0) the tree comprises four main subgroups: neurons, Oligo, AstroEpen and other non-neuronal (NN) cells. Subsequent levels C1–C3 further define the cell-type structure in the human hypothalamus. For neurons, a further level C4 with up to 452 total clusters exists (not shown). Edges are labelled with cluster names. The heatmap ring depicts the relative contribution of cells by the two studies to each cluster on level C3. Further information on tree structure, cluster annotation and marker genes can be found in Supplementary Tables 5–8.