Extended Data Fig. 5: Histopathological features in mice and human HCC within the same cluster are comparable.
From: Human-correlated genetic models identify precision therapy for liver cancer
(a) Transcriptional subclasses translate to similar histopathologies between human and mouse liver samples from the same HuMo clusters as shown by H&E staining; representative images from n = 4 biological replicates in each HuMo shown. Scale bars equal 200 µm. (b-d) Analysis of tumour grade (b + c) and steatohepatitis (d) highlights the resemblance of human (n = 334) and mouse (n = 147) HCC within the same HuMo cluster. Dots/bars as log odds ratio/95% Cis respectively; Fisher test, >0.05 (open circles) and ≤0.05 (closed circles). Scanned whole liver lobes across biological replicates from each cohort are available via BioImage Archive (https://www.ebi.ac.uk/) via accession number S-BIAD1365.
