Extended Data Fig. 4: Mutational status alone does not explain cluster association. | Nature

Extended Data Fig. 4: Mutational status alone does not explain cluster association.

From: Human-correlated genetic models identify precision therapy for liver cancer

Extended Data Fig. 4: Mutational status alone does not explain cluster association.The alternative text for this image may have been generated using AI.

(a) UMAP plots showing distribution of mouse cohorts by specific genetic alterations, carcinogen treatment (TOX), or orthotopic transplant (OT). (b-f) Samples with mutated CTNNB1/Ctnnb1 (b) are spread over the whole UMAP spectrum, whereas samples with expression of beta-catenin pathway downstream targets GLUL/Glul (c), LGR5/Lgr5 (d), LECT2/Lect2 (e), and NOTUM/Notum (f) are confined to the upper left quadrant.

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