Fig. 3: TRACERx 421 cohort analyses.
From: Clonal driver neoantigen loss under EGFR TKI and immune selection pressures
Clonality of all pre-WGD mutations from tumour regions with evidence of WGD. Each column represents a single region from the TRACERx 421 cohort. The median proportion of pre-WGD mutations that were also clonal at a region level is 99.4% (IQR = 96.6–1). Regions in which pre-WGD mutations have a high proportion of subclonal mutations are enriched for tumours with subclonal WGD events and tumours that have a higher number of sequenced regions.
