Extended Data Fig. 3: ctDNA analyses.
From: Clonal driver neoantigen loss under EGFR TKI and immune selection pressures
a, Low pass whole genome sequencing to assess for ctDNA content and explore gains and losses. b, ctDNA Mutant allele frequencies (AF) at sampled timepoints. The colours reflect the phylogenetic tree clusters. c, Zoomed in view of the ctDNA mutant allele frequencies, focussing on AF less than 0.015. Timepoints represent primary lung biopsy (0 months), RUL metastasis (19 months), RUL progression post osimertinib (30 months), SCLC transformed liver metastasis (38 months) & Mediastinal mass (45 months) RUL = right upper lobe, SCLC = small cell lung cancer.
