Extended Data Fig. 5: Transcriptional dysregulation in brain endothelial glycosylation pathways in neurodegenerative diseases.
From: Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease
a) Volcano plot of differentially expressed glyco-genes in brain endothelial cells from patients with Alzheimer’s disease (AD) and age-matched control individuals (genes upregulated with AD in red and genes downregulated with AD in blue). Original snRNA-seq data from Yang, et al.26. b) Top upregulated and downregulated glycosylation-related pathways in brain endothelial cells in patients with AD versus age-matched control individuals. c) Volcano plot of differentially expressed glyco-genes in brain endothelial cells from patients with Huntington’s disease (HD) and age-matched control individuals (genes upregulated with HD in red and genes downregulated with HD in blue). Original snRNA-seq data from Garcia, et al.27. d) Top upregulated and downregulated glycosylation-related pathways in brain endothelial cells in patients with HD versus age-matched control individuals. e) Venn diagram of significantly upregulated brain endothelial glyco-genes that are shared amongst mouse aging, AD, and HD datasets. f) Venn diagram of significantly downregulated brain endothelial glyco-genes that are shared amongst mouse aging, AD, and HD datasets. Mucin-type O-glycan biosynthetic enzymes are highlighted in purple.
