Fig. 5: The fitness landscape of known drivers of clonal haematopoiesis.
From: Clonal dynamics and somatic evolution of haematopoiesis in mouse
a, Reverse cumulative density for all synonymous (including flanking intronic regions in targeted baitset) and non-synonymous somatic variants detected using duplex sequencing from mice aged 24–25 months, arranged by increased VAF. The relative density of synonymous (and flanking intronic) variants, which are assumed to have neutral fitness, yields an estimate for N/λ, the ratio of population size and symmetric cell division rate (per year). The synonymous and non-synonymous mutation rates (μ, bp per year) can then be estimated using a maximum-likelihood approach. b, Distribution of fitness effects for non-synonymous mutations.
