Extended Data Fig. 14: Aspirin promotes immunity to cancer metastasis by releasing T cells from ARHGEF1-dependent suppression by TXA2.
From: Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity
Graphical schema of study findings. Platelets produce TXA2 which binds to its receptor (TP) on T cells, triggering the activation of ARHGEF1, a guanine exchange factor which facilitates the conversion of inactive GDP-bound RhoA into its active GTP-bound conformation. Activation of RhoA inhibits TCR-driven kinase pathways, proliferation and effector functions of T cells, thereby suppressing anti-metastatic immunity. Production of TXA2 by platelets is COX1-dependent and inhibited by aspirin and COX-1 selective inhibitors, which release T cells from TXA2-mediated suppression. Created in BioRender. Roychoudhuri, R. (2025) https://BioRender.com/u42p292.
